英語原著論文

1, Numazawa M, Ohkubo T, Nambara T : Preparation of antiserum
specific for oestradiol 17- glucuronide.
FEBS Lett, 79 : 215-218, 1977

2, Nambara T, Numazawa M, Tanaka T, Ohkubo T : Preparation of
specific antisera to estriol 16-glucuronide by immunization with
steroids attached to protein through positions in ring A.
J Pharm Dyn, 1 : 55-61, 1978

3, Nambara T, Numazawa M, Tanaka T, Ohkubo T : Preparation of
specific antisera to estradiol 17-glucuronide.
J Steroid Biochem, 9 : 785-790, 1978

4, Nambara T, Ohkubo T, Shimada K : A simple radioimmunoassay
for estrone sulfate in unextracted plasma without deconjugation.
Jpn J Clin Chem, 11 : 339-343, 1982

5, Nambara T, Ohkubo T , Shimada K : Determination of estrone
sulfate in plasma by radioimmunoassay without deconjugation.
Clin Chem Acta, 119 : 81-87, 1982

6, Nambara T, Shimada K, Ohkubo T , Niwa T : Preparation and
antigenic properties of estriol 16-glucuronide and estradiol 17-
glucuronide-[C-6]-bovine serum albumin conjugate.
J Steroid Biochem, 16 : 533-538, 1982

7, Shimada K, Ohkubo T, Tanaka M, Yoshida F, Nambara T :
Preparation of specific antiserum to estradiol 3-glucuronide.
J Steroid Biocheｍ, 17 : 511-515, 1982

8, Nambara T, Ohkubo T, Yamaki T, Shimada K : A direct
radioimmunoassay of estradiol 3-glucuronide using specific
antiserum.
Chem Pharm Bull, 31 : 3583-3588, 1983

9, Nambara T, Ohkubo T , Shimada K: Antigenic properties of estriol
3-glucuronide-[C-6]-bovine serum albumin conjugates having　oxime　bridges.
J Pharm Dyn, 6 : 692-697, 1983

10, Nambara T, Ohkubo T, Yamaki T, Shimada K : Preparation of
specific antisera to estrone 3-glucuronide and estriol 3-
glucuronide.
J Steroid Biochem, 20 : 621-626, 1984

11, Honjo H, Otsubo K, Yasuda J, Kitawaki J, Okada H, Ohkubo T ,
Nambara T : Conjugated oestrogen during the menstrual cycle
measured by a direct radioimmunoassay with an antiserum
prepared against oestradiol 17-glucuronide-[C-6]-BSA conjugate.
Acta Endocrinol, 106 : 374-380, 1984

12, Shimada K, Mizusawa S, Ohkubo T , Nambara T : Preparation of
specific antisera to digoxin using hapten-[C-17] and [C-12]-
bovine serum albumin conjugate.
Chem Pharm Bull, 32 : 2301-2306, 1984

13, Honjo H, Kitawaki J, Itoh M, Yasuda J, Yamamoto T, Yamomoto
T, Okada H, Ohkubo T , Nambara T : Serum and urinary oestrone
sulfate in pregnancy and delivery measured by a direct
radioimmunoassay.
Acta Endocrinol, 112 : 423-430, 1986

14, Honjo H, Kitawaki J, Itoh M, Yasuda j, Iwasaku K, Urabe M,
Naitoh M, Yamamoto T, Okada H, Ohkubo T , Nambara T : Serum
and urinary estrone sulfate during the menstrual cycle, measured
by a direct radioimmunoassay and fate of exogenously injected estrone sulfate.
Hormone Res, 27 : 61-68, 1987

15, Ohkubo T, Tsuchiko F, Nambara T : New synthesis of 2-
hydroxyestrogen 2-monoglucuronides.
Chem Pharm Bull, 36 : 419-423, 1988

16, Ohkubo T, Wakasawa T, Nambara T : Preparation of specific antiserum to 2-hydroxyestrone.
Jpn J Clin Chem, 17 : 1-8, 1988

17, Ohkubo T, Tsuchiko F, Wakasawa T, Nambara T : Preparation and
antigenic properties of 2-hydroxyestrone-[C-15]-bovine serum
albumin conjugate.
Chem Pharm Bull, 36 : 3519-3524, 1988

18, Ohkubo T, Wakasawa T, Shimada K, Nambara T: Separation of
isomeric 2-hydroxyestriol monoglucuronides and monosulfates
by high-performance liquid chromatography with dual-electrode
coulometric detection.
J Liq Chromatogr, 12 : 2093-2102, 1989

19, Ohkubo T, Wakasawa T, Nambara T : Synthesis of 2-hydroxyestriol monoglucuronides and mono- sulfates.
Steroids, 55 : 128-132, 1990

20, Ohkubo T, Takahashi A, Nambara T : Multiplicity of in vitro
glucuronidation of 2-hydroxyestriol.
J Steroid Biochem, 36 : 501-503, 1990

21, Ohkubo T , Nambara T : Determination of mitomycin C in serum
by high-performance liquid chromatography with dual electrode
coulometric detection.
J Chromatogr, 527 : 441-446, 1990

22, *Ohkubo T, Kudo M, Sugawara K : High-performance liquid
chromatographic determination of ofloxacin in serum.
Anal Sci, 7 : 741-743, 1991

23, *Ohkubo T, Uno T, Sugawara K : Determination of propylthiouracil
in human breast milk by direct injection high-performance liquid chromatography.
J Liq Chromatogr, 14 : 2745-2753, 1991

24, *Ohkubo T , Sugawara K : The mechanism for discoloration of
admixture of Alimezine, Inolin and Leftose syrup.
Jpn J Hosp Pharm, 18 : 59-65, 1992

25, *Ohkubo T, Kudo M, Sugawara K : Determination of ofloxacin in
human serum by high-performance liquid chromatography with column switching.
J Chromatogr, 573 : 289-293, 1992

26, *Ohkubo T, Sugawara K, Sato Y, Suzuki Y : Color change of new
coccine in a lysozyme-alimezine-trimeto-quinol syrup: Optical
spectroscopic and kinetic analysis.
Chem Pharm Bull, 40 : 811-814, 1992

27, *Ohkubo T, Uno T, Sugawara K : Enantiomer separation of
dihydropyridine derivatives by liquid chromatography with chiral
stationary phase.
Chromatographia, 33 : 287-288, 1992

28, *Ohkubo T, Noro H, Sugawara K : High-performance liquid
chromatographic determination of nifedipine and trace
photodegradation product in hospital prescription.
J Pharm Biomed Anal, 10 : 67-70, 1992

29, *Ohkubo T, Shimoyama R, Sugawara K : Measurement of haloperidol in
human breast milk in high-performance liquid chromatography.
J Pharm Sci, 81 : 947-949, 1992

30, *Ohkubo T, Sugawara K : The mechanism for acceleration effect
of discoloration of new coccine with lysozyme in the admixtures
of Alimezine syrup, Inolin syrup and Leftose syrup.
Jpn J Hosp Pharm, 18 : 443-448, 1992

31, *Ohkubo T, Shimoyama R, Sugawara K : Determination of chlorpromazine
in human breast milk and serum by high- performance　liquid
chromatography.
J Chromatogr, 641 : 328-332, 1993

32, *Ohkubo T, Shimoyama R, Sugawara K : High-performance　liquid
chromatographic determination of levomepromazine in serum and human
breast milk.
Biomed Chromatogr, 7 : 227-228, 1993

33, Sawada Y, Ohkubo T, Kudo M, Sugawara K : Tissue concentration of orally administered antimicrobial agent in scar tissue, granulation tissue, normal skin and serum.
Burns, 19 : 529-530, 1993

34, *Ohkubo T, Kudo M, Sugawara K, Sawada Y : The determination
of ofloxacin in human skin tissue by high-performance liquid
chromatography and correlation of skin tissue concentration and
serum level of ofloxacin.
J Pharm Pharmacol , 46 : 522-524, 1994

35, *Ohkubo T, Uno T, Saugawara K : Enantiomer separation of
dihydropyridine derivative calcium antagonists by high-
performance liquid chromatography with chiral stationary phase.
J Chromatogr A, 659 : 467-471, 1994

36, Sawada Y, Ohkubo T, Kudo M, Sugawara K, Otani K, Sasaki J : An
evaluation of a new lactic acid polymer drug delivery system : a
preliminary report.
Br J Plast Surg, 47 : 158-161, 1994

37, *Ohkubo T, Osanai T, Sugawara K, Ishida M, Otani K, Mihara K,
Yasui N : High-performance liquid chromatographic determination
of trazodone and 1-m-chlorophenylpiperazine with ultraviolet
and electrochemical detector.
J Pharm Pharmacol, 47 : 340-344, 1995

38, Otani K, Yasui N, Kaneko S, Ishida M, Ohkubo T, Osanai T,
Sugawara K, Fukushima Y: Trazodone treatment increases plasma prolactin concentrations in depressed patients.
Int Clin Psychopharmacol, 10 : 115-117, 1995

39, Yasui N, Otani K, Kaneko S, Ohkubo T, Osanai T, Ishida M, Mihara K, Kondo T, Sugawara K, Fukushima Y : Inhibition of trazodone metabolism by thioridazine in man.
Ther Drug Monit, 17 : 333-335, 1995

40, Ishida M, Otani K, Kaneko S, Ohkubo T, Osanai T, Yasui N, Mihara K, Higuchi H, Sugawara K, Fukushima Y: Effects of
various factors on steady-state plasma concentrations of trazodone
and its active metabolite m-chlorophenylpiperazine.
Int Clin Psychopharmacol, 10 : 143-146, 1995

41, Tanaka M, Kato K, Sudo K, Hakusui H, Ohkubo T, Sugawara K,
Kaneko S, Otani K , Chiba K, Ishizaki T : Simple and selective
assay of 4-hydroxymephenytoin in human urine using solid-phase extraction and high performance liquid chromatography with electrochemical detection and its preliminary application to phenotyping test.
J Chromatogr B, 676 : 87-94, 1996

42, Yashui N, Otani K, Kaneko S, Ohkubo T, Osanai T, Sugawara K,
Chiba K, Ishizaki T : A kinetic and dynamic study of oral alprazolam with and without erythromycin in humans ： In vivo evidence for the involvement of CYP3A4 in alprazolam metabolism.
Clin Pharmacol Ther , 59 : 514-519, 1996

43, Otani K, Yashui N, Kaneko S, Ohkubo T, Osanai T, Sugawara K :
Carbamazepine augmentation therapy in three patients with
trazodone-resistant unipolar depression.
Int Clin Psychopharmacol, 11 : 55-57, 1996

44, *Ohkubo T, Suno M, Kudo M, Uno T, Sugawara K : Column switching high-performance liquid chromatography of ofloxacin in human saliva and correlation between saliva and serum level.
Ther Drug Monit, 18 : 598-603, 1996

45, Otani K, Ishida M, Kaneko S, Mihara K, Ohkubo T, Osanai T, Sugawara K : Effects of carbamazepine coadministration on plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine.
Ther Drug Monit, 18 : 164-167, 1996

46, *Ohkubo T, Uno T, Sugawara K : Liquid chromatographic determination of manidipine in serum with electrochemical detection.
J Chromatogr B, 687 : 413-418, 1996

47, Sugawara K, Ohkubo T, Nagasaki T, Hayakari M : Angiotensin-
converting enzyme inhibitory activity of Kampo medicines.
Res Drug Act Interact, 20 : 29-37, 1996

48, Otani K, Yasui N, Kaneko S, Ohkubo T, Osanai T, Sugawara K,
Hayashi K, Chiba K, Ishizaki T : Effects of genetically determined
s-mephenytoin 4-hydroxylation status and cigarette smoking on the single-dose pharmacokinetics of oral alprazolam.
Neuropsychopharm, 16 : 8-14, 1997

49, Nagasaki T, *Ohkubo T, Sugawara K, Yasui Y, Otani K, Kaneko S : Determination of alprazolam and α-hydroxyalprazolam in plasma by high-performance liquid chromatography.
Anal Sci, 13 : 245-249, 1997

50, Mihara K, Otani K, Ishida M, Yasui N, Suzuki A, Ohkubo T, Osanai T, Kaneko S, Sugawara K : Increases in plasma concentration of m-chlorophenylpiperazine, but not trazadone, with low-dose haloperidol.
Ther Drug Monit, 19 : 43-45, 1997

51, Otani K, Mihara K, Yasui N, Ishida M, Kondo T, Tokinaga N,
Ohkubo T, Nagasaki T, Sugawara K, Kaneko S : Plasma
concentrations of trazodone and m-chlorophenylpiperazine at
steady state can be predicted from those after an initial dose of
trazodone.
Prog Neuro-Psychopharmacol Biol Psychiat, 21 : 239-244, 1997

52, Otani K, Yasui N, Furukori H, Kaneko S, Tasaki H, Ohkubo T,
Nagasaki T, Sugawara K, Hayashi K : Relationship between single
oral dose pharmacokinetics of alprazolam and triazolam.
Int Clin Psychopharmacol, 12 : 153-157, 1997

53, Uno T, *Ohkubo T , Sugawara K : Enantioslective high-performance liquid chromatographic determination of nicardipine in human plasma.
J Chromatogr B, 698 : 181-186, 1997

54, Yasui N, Otani K, Kaneko S, Shimoyama R, Ohkubo T, Sugawara
K : Carbamazepine toxicity induced by clarithromycin coadministration inpsychiatric patients.
Int Clin Psychopharmacol, 12 : 225-229, 1997

55, Mihara K, Otani K, Suzuki A, Yasui N, Nakano H, Meng X, Ohkubo T, Nagasaki T, Kaneko S,Tsuchida S, Sugawara K, Gonzalez FJ : Relationship between the CYP2D6 genotype and the steady state plasma concentration of trazodone and its active metabolite m-chlorophenylpiperazine.　
Psychopharmacology, 133 : 95-98, 1997

56, Takeshita M, Miura M, Hongo T, Ohkubo T, Sugawara K, Kosaka
K, Takeshita Y, Araki T, Ohshima Y : Synthesis and cataleptic
effects of optically active dihydrohaloperidols and
dihydrobromoperidols.
Chirality, 9 : 443-445, 1997

57, Tanaka M, Ohkubo T, Otani K, Suzuki A, Kaneko S, Sugawara K,
Ryokawa Y, Hakusui, Yamamori S, Ishizaki T : Metabolic disposition of pantoprazole, a proton pump inhibitor, in relation to S-mephenytoin 4'-hydroxylation phenotype and genotype.
Clin Pharmacol Ther, 62 : 619-628, 1997

58, Otani K, Kondo T, Yasui N, Sizuki A, Furukori H, Kaneko S, Ohkubo T, Nagasaki T, Sugawara K, Hayashi K : Prolactin response to nemonapride, a new antipsychotic drug in schizophrenic patients.
Human Psychopharmacol, 12 : 591-594, 1997

59, Uno T, *Ohkubo T, Sugawara K, Higashiyama A, Motomura S :Effects of Shigyaku-san (TJ-35) on pharmacokinetics and pharmacodynamics of nicardipine.
Res Drug Act Interact, 21 : 139-145, 1998

60, Furokori H, Otani K, Yasui N, Kondo T, Kaneko S, Shimoyama R,
Ohkubo T, Nagasaki T, Sugawara K : Effect of carbamazepine on the single oral dose pharmacokinetics of alprazolam.
Neurophychopharmacol, 18 : 364-369, 1998

61, Otani K, Tybring G, Mihara K, Yasui N, Kaneko S, Ohkubo T,
Nagasaki T, Sugawara K : Correlation between steady-state plasma concentrations of mianserin and trazodone in depressed patients.
Eur J Clin Pharmacol, 53 : 347-349, 1998

62, Shimoyama R, *Ohkubo T, Sugawara K, Ogasawara T, Ozaki T, Kagiya A, Saito Y : Monitoring of phenytoin in human breast milk, maternal plasma and cord blood plasma by solid-phase extraction and liquid chromatography.
J Pharmaceut Biomed Anal, 17 : 863-869, 1998

63, Nagasaki T, *Ohkubo T, Sugawara K, Yasui N, Otani K, Kaneko S
: High-performance liquid chromatographic determination of
nemonapride and desmethylnemonapride in human plasma using an electrochemical detection.
J Chromatogr B, 714 : 293-298, 1998

64, Yasui N, Kondo T, Otani K, Furukori H, Kaneko S, Ohkubo T,
Nagasaki T, Sugawara K : Effect of itraconazole on the single oral
dose pharmacokinetics and pharmacodynamics of alprazolam.
Psychopharmacology, 139 : 269-273, 1998

65, Yotsuyanagi T, Urushidate S, Yokoi K, Sawada Y, Suno M, Ohkubo T :
A study of the concentration of orally administered sparfloxacin found in exudates from suture wounds beneath occlusive dressings.
Burns, 24 : 751-753, 1998

66, Kudo M, *Ohkubo T, Sugawara K : Determination of sparfloxacin in plasma by direct injection high performance liquid chromatography with column switching.
J Liq Chromatogr Rel Technol, 22 : 441-449, 1999

67, Nagasaki T, *Ohkubo T, Sugawara K, Yasui N, Furukori H, Kaneko S : Determination of risperidone and 9-hydroxyisperi-
done in human plasma by high-performance liquid chromatography: Application to therapeutic drug monitoring in Japanese patients with schizophrenia.
J Pharmaceut Biomed Anal, 19 : 595-601, 1999

68, Sawada Y, Yokoi K, Ohkubo T, Murata Y, Ishita K : The relationship between flap survival and dressing materials.
Eur J Plast Surg, 22 : 22-24, 1999

69, Uno T, *Ohkubo T , Sugawara K : Enantioselective hig-performance liquid chromatographic determination of manidipine in human plasma.
J Liq Chromatogr Rel Technol, 22 : 1117-1128, 1999

70, Shimoyama R, *Ohkubo T , Sugawara K : Monitoring of zonisamide in human breast milk and maternal plasma by solid-phase extraction HPLC method.
Biomed Chromatogr, 13 : 370-372, 1999

71, Kudo M, *Ohkubo T ,Sugawara K : Determination of Fleroxacin in plasma by direct injection high performance liquid chromatography with column switching.
Anal Lett, 32 : 1589-1601, 1999

72, Kudo M, *Ohkubo T, Sugawara K : Determination of tosufloxacin in plasma by high-performance liquid chromatography with column switching.
Jap J Hosp Pharm, 25 : 595-602, 1999

73, Shimoyama R, *Ohkubo T , Sugawara K : Characteristics of interaction between barbiturate derivatives and various solvents on liquid chromatography and determination of phenobarbital in Japanese human breast milk.
J Liq Chromatogr Rel Technol, 23 : 587-599, 2000

74, Shimoyama R, *Ohkubo T, Sugawara K : Monitoring of carbamazepine and carbamazepine 10,11-epoxide in breast milk and plasma by high-performance liquid chromatography.
Anna Clin Biochem, 37 : 210-215, 2000

75, Takeshita M, Miura M, Ohkubo T, Sugawara K : Asymmetric redox reactions in human liver stereoselective oxidation of optically active dihydrohaloperidols, dyhydrobromoperidols and stereospecific reduction of haloperidol and bromoperidol.
Enantiomer, 5 : 189-195, 2000

76, Kondo T, Mihara K, Yasui N, Nagashima U, Ono S, Kaneko S, Ohkubo T, Osanai T, Sugawara K, Otani K : Therapeutic spectrum of nemonapride and its relationship with plasma concentration of the drug and prolactin.
J Clin Psychopharmacol, 20, 404-409, 2000

77, Yasui N, Kondo T, Furukori H, Kaneko S, Ohkubo T, Uno T, Osanai T, Sugawara K, Otani K : Effects of repeated ingestion of grapefruit juice on the single and multiple dose pharmacokinetics and pharmacodynamics of alprazolam.
Psychopharmacology, 150 : 185-190, 2000

78, Uno T, *Ohkubo T, Sugawara K, Higashiyama A, Motomura S, Ishizaki T : Efeects of grapefruit juice on the stereoslective disposition of nicardipine in human: An evidence for dominant presystemic elimination at the gut site.
Eur J Clin Pharmacol , 56 : 643-649, 2000

79, Tanaka M, Ohkubo T, Otani K, Suzuki A, Kaneko S, Sugawara K,
Ryokawa Y, Ishizaki T : Stereoselective pharmacokinetics of
pantprazole, a proton pump inhibitor, in extensive and poor
metabolizers of S-mephenytoin.
Clin Pharmacol Ther, 69, 108-113, 2001

80, Kanazawa S, *Ohkubo T, Sugawara K : The effects of grapefruit juice on the pharmacokinetics of erythromycin.
Eur J Clin Pharmacol, 56,799-803, 2001

81, Yasui-Furukori N, Kondo T, Kubota T, Otake H, Ohkubo T, Nagasaki T, Sgawara K, Chiba K, Otani K, Kaneko S: No correlation between the urinary ratio of 6β-hydroxycortisol to free cortisol and pharmacokinetics of alprazolam.
Eur J Clin Pharmacol, 57, 285-288, 2001

82, Yoshida K, Ito K, Sato K, Takahashi H, Kamata M, Higuchi H, Shimizu T, Ito K, Inoue K, Tezuka T, Suzuki T, Ohkubo T, Otani K : Influence of the serotonin transporter gene-linked polymorphic region on the antidepressant response to fluvoxamine in Japanese depressed patients.
Prog Neuropsychopharmacol Biol Psychitry,26, 383-386, 2002

83, Otsuji Y, Okuyama N, Aoshima T, Fukasawa T, Kato K, Gerstenberg G, Miura M, Ohkubo T, Otani K : No effect of itraconazole on the single oral dose pharmacokinetics and pharmacodynamics of estazolam.
Ther Drug Monit, 24, 375-378, 2002

84, Miura M, *Ohkubo T, Sugawaga K, Okuyama N, Otani K : Determination of estazolam in plasma by high-performance liquid chromatography with solid-phase extraction.
Anal Sci, 18, 525-528, 2002

85, Mihara K, Yasui-Furukori N, Kondo T, Ishida M, Ono S, Ohkubo T, Osanai T, Sugawara K, Otani K, Kaneko S : Relationshipbetween plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients.
Ther Drug Monit, 24, 563-566, 2002

86, Tkahashi H, Yoshida K, Ito K, Sato K, Kamata M, Higuchi H, Shimizu T, Ito K, Inoue K, Tezuka T, Suzuki T, Ohkubo T, Sugawara K : No association between the serotonergic polymorphisms and incidence of nausea induced by fluvoxamine treatment.
Eur Neuropsychopharmacol, 12, 477-481, 2002

87, Ito K, Yoshida K, Sato K, Takahashi H, Kamata M, Higuchi H, Shimizu T, Ito K, Inoue K, Tezuka T, Suzuki T, Ohkubo T, Sugawara K, Otani K : A variable number of tandem repeats in the serotonin transporter gene dose not affect the antidepressant response to fluvoxamine.
Psychiatry Res, 111, 235-239, 2002

88, Sato K, Yoshida K, Takahashi H, Ito K, Kamata M, Higuchi H, Shimizu T, Ito K, Inoue K, Tezuka T, Suzuki T, Ohkubo T, Sugawara K, Otani K : Association between -1438G/A promoter polymorphism in the 5-HT(2A) receptor gene and fluvoxamine response in Japanese patients with major dpressive disorder.
Neuropsychobiology, 46, 136-140, 2002

89, Yoshida K, Naito S, Takahashi H, Sato K, Ito K, Kamata M, Higuchi H, Shimizu T, Ito K, Inoue K, Tezuka T, Suzuki T, Ohkubo T, Sugawara K, Otani K : Monoamine oxidase : A gene polymorphism, tryptophan hydroxylase Japanese patients with major dpressive disorder.
Prog Neuropsychopharmacol Biol Psychiatry, 26, 1279-1283, 2002

90, Aoshima T, Fukasawa T, Otsuji Y, Okuyama N, Gerstengerg G, Miura M, Ohkubo T, Otani K : effects of the CYP2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam.
Prog Neuropsychopharmacol Biol Psychiatry, 27, 535-538, 2003

91, Gerstenberg G, Aoshima T, Fukazawa T, Yoshida K, Takahashi H, Higuchi H, Murata Y, Shimoyama R, Ohkubo T, Shimizu T, Otani K : Relationship between clinical effects of fluvoxamine and the steadystate plasma concentrations of fluvoxamine and its major metabolite fluvoxamino acid in Japanese dpressed patients.
Psychopharmacology, 167, 443-448, 2003

92, *Ohkubo T, Shimoyama R, Otani K, Yoshida K, Higuchi H, Shimizu T : High-performance liquid chromotographic determination of fluvoxamine and fluvoxamino acid in human plasma.
Anal Sci, 19, 859-864, 2003

93, Gerstenberg G, Aoshima T, Fukazawa T, Yoshida K, Takahashi H, Higuchi H, Murata Y, Shimoyama R, Ohkubo T, Shimizu T, Otani K : Effects of the CYP 2D6 genotype and cigarette smoking on the steady-state plasma concentration of fluvoxamine and its major metabolite fluvoxamino acid in Japanese depressed patients.
Ther Drug Monit, 25, 463-468, 2003

94, Osanai T, *Ohkubo T. : Development of high-performance liquid chromatographic method for determination of brotizolam on clinical pharmacokinetic study. Anal Lett, 36, 3025-3034,2003.

95, Echizenya M, Mishima K, Satoh K, Kusanagi H, Sekino A, Ohkubo T, Shimizu T, Hishikawa Y : Heat loss, sleepiness, and impaired performance after diazepam administration in humans.
Neuropsychopharmacol, 28, 1198-1206, 2003.

96, Yoshida K, Naito S, Takahashi H, Sato K, Ito K, Kamata M, Higuchi H, Shimizu T, Itoh K, Inoue K, Suzuki T, Ohkubo T : Gene polymorphism and incidence of nausea induced by fluvoxamine.
Neuropsychobiol. 48, 10-13, 2003.

97, Guan W, Osanai T, Kamada T, Hanada H, Ishizaki H, Onodera H, Iwasa A, Fjita N, Kudo S, Ohkubo T, Okumura K : Effect of allopurinol pretreatment on free radical generation after primary coronary angioplasty for acute myocardial infarction.
J Cardiova Pharmacol, 41, 699-705, 2003.

98, Zhu G, Okada M, Uchiyama D, Ohkubo T, Yoshida S, Kaneko S : Hyperactuvity of endoplasmic reticulum associated exocytosis mechanism contributes to acute phencyclidine intoxication. J Pharmacol Sci, 95, 214-227, 2004.

99, Echizenya M, Mishima K, Satoh K, Kusanagi H, Sekine A, Ohkubo T, Shimizu T, Hishikawa Y: Enhanced heat loss and age-related hypersensitivity to diazepam. J Clin Psychopharmacol, 24, 639-646, 2004.

100, Osanai T, *Ohkubo T, Yasui N, Kondo T, Kaneko S : Effect of itraconazole
on the pharmacokinetics and pharmacodynamics of a single oral dose of
brotizolam. Brit J Clin Pharmacol, 58, 476-481, 2004.

101, Miura M, *Ohkubo T : In vitro metabolism of quazepam in human liver and intestine and assessment of drug interactions. Xenobiotica, 34, 1001-1011, 2004.

102, *Ohkubo T, Osanai T : Determination of itraconazole in human plasma by high-performance liquid chromatography with solid-phase extraction. Ann Clin Biochem, 42, 94-98, 2005

103, Miura M, Otani K, *Ohkubo T : Identification of human CYP isoforms involved in the formation of 4-hydroxyestazolam from estazolam. Xenobiotica, 35, 455-465, 2005

104, Hojo Y, Echizenya M, Ohkubo T, Shimizu T : Drug interaction between St John’s wort and zolpidem in healthy subjects. J Clin Pharmacol Ther, 36, 711-715, 2011

105, Akamine Y,Kagaya H, Ohkubo T, Satoh S, Miura M : A comparrison of the effects of CYP3A5 polymorphism on tacrolimus blood concentration measured by 4 immunoassay methods in renal transplant patients. J Clin Pharm Ther, 1-8, 2017

106, Akamine Y, Sato S, Kagaya H, Ohkubo T, Satoh S, Miura M : Comparrison of electorochemiluminescence immunoassay and latex agglutination turbidimetoric immunoassay for evaluation of everolimus blood concentration in renal transplant patients. J Clin Pharm Ther, 43, 675-681,2018

107,Ohkubo S, Akamine Y, Ohkubo T, Kikuchi Y, Miura M : Quantification of the plasma concentrations of perampanel using high-performance liquid chromatography and effects of the CYP3A4*1G polymorphism in Japanese patients. J Chromatgr Sci, , Sep 5, 1-7,2020

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日本語原著論文

1．岩破　一博，本庄　英雄，藤本　泰子，保田　仁介，岡田　弘二，
杉本　徹，沢田　淳，大久保　正，南原　利夫。
思春期における血清，尿中estrogen，特にestrone sulfate(E1-S)について。
思春期学，5，214-218（1987）

2．千田　敏，奈良　武志，大久保　正。
特異抗血清を用いるラジオイムノアッセイによる血漿中Dihydroergotoxine
の測定。
薬学雑誌，108，58-65（1988）

3．大久保　正, 野呂　秀紀, 須野　学, 工藤　正純, 宇野　司, 下山　律子,藤田　祥子, 大泉　昭良, 桜田　健, 菅原　和信
薬剤管理指導料（600点）認可に向けてのアンケート調査結果（医師部門）。
病院薬学、22、246-255（1996）

4．野呂　秀紀, 大久保　正, 須野　学, 工藤　正純, 宇野　司, 下山　律子,藤田　祥子, 大泉　昭良, 桜田　健, 菅原　和信
薬剤管理指導料（600点）認可に向けてのアンケート調査結果（看護婦部門）。
病院薬学、22、256-264（1996）

5．野呂　秀紀，大久保　正，岩木川　直子，長崎　尊子，金澤　佐知子，村田　佳子，新岡　丈典，須野　学，工藤　正純，宇野　司，下山　律子，菅原　和信
東北6件と新潟県における薬剤管理指導業務調査（1）（各施設の現状）
医薬品相互作用研究，22，81-87（1999）

6．大久保　正，野呂　秀紀，岩木川　直子，長崎　尊子，金澤　佐知子，村田　佳子，新岡　丈典，須野　学，工藤　正純，宇野　司，下山　律子，菅原　和信
東北6件と新潟県における薬剤管理指導業務調査（2）（薬剤管理指導業務の内容と質）
医薬品相互作用研究，22，89-96（1999）

7．野呂　秀紀，大久保　正，岩木川　直子，長崎　尊子，金澤　佐知子，村田　佳子，新岡　丈典，須野　学，工藤　正純，宇野　司，下山　律子，菅原　和信
東北6件と新潟県における薬剤管理指導業務調査（3）（薬剤管理指導業務に伴う薬剤師の仕事量と薬剤師の意識）
医薬品相互作用研究，22，97-102（1999）

8．野呂　秀紀，大久保　正，下山　律子，宇野　司，工藤　正純，須野　学，新岡　丈典，金澤　佐知子，菅原　和信
東北6県と新潟県の病院薬剤部での医薬品情報業務に関する実態調査（1）。
病院薬剤師会雑誌，35，1113-1116（1999）

9．大久保　正，野呂　秀紀，下山　律子，宇野　司，工藤　正純，須野　学，新岡　丈典，金澤　佐知子，菅原　和信
東北6県と新潟県の病院薬剤部での医薬品情報業務に関する実態調査（2）。
病院薬剤師会雑誌，35，1117-1121（1999）

10．大久保　正，野呂　秀紀，神　雅昭，菅原　和信
薬の情報提供について弘前大学病院勤務医に対するアンケート調査。
病院薬学，25，460-471（1999）

11．大久保　正，野呂　秀紀，新岡　丈典，菅原　和信
当院院外処方せんにみられる非ステロイド性消炎鎮痛薬と抗潰瘍薬併用投与についての実態調査。
医薬品相互作用研究，23，97-102（1999）

12. 佐藤　洋子，野呂　秀紀，工藤　正純，金沢　佐知子，福士　涼子，長内　尊子，藤田　祥子，大久保　正，菅原　和信
当院における外来患者さんからのお薬相談の実態調査。
医薬品相互作用研究，25，9-13（2001）

13. 新岡　丈典，大久保　正，鳴海　俊治，袴田　健一，十束　英志，豊木　嘉
一，佐々木　睦男，小島　桂也，保嶋　実，菅原　和信
生体肝移植患者におけるタクロリムスの消失速度定数(ke)と臨床検査値との相関。
TDM研究，19，348-354（2002）

14. 金沢　久男，高嶋　宏悦，大久保　正
輸液と総合ビタミン注射製剤の混合によりTPN投与セットにおける滴下速度の減少をもたらす原因の解明。
医療薬学，29，159-164（2003）

15.　大久保　正
　　リン酸エストラムスチンカプセルの経鼻チューブ投与時における溶液の調整法と溶液状態における安定性
　　医薬ジャーナル，39，2571-2575 (2003)

16. 大久保　正
　　0.5%ヒベンズ酸チペピジンシロップ後発品と塩化リゾチームシロップの混合による白色沈殿の生成機構と調剤上の問題がもたらす後発品採用の是非。
　　薬局, 54, 2871-2874 (2003)

17. 新岡　丈典, 大久保　正, 川崎　仁司, 柴田　滋, 村田　暁彦, 鳴海　俊治, 袴田　健一, 小田切　弘毅, 森田　隆幸, 佐々木　睦男, 小島　桂也, 保嶋　実
　　母集団パラメータを用いたテイコプラニン血中濃度の予測精度に関する検討。
　　TDM研究, 21, 33-40 (2004)

18. 大久保　正
　　塩酸セフォチアム注射製剤における先発製剤と後発製剤の不溶性微粒子比較試験による品質評価。
　　化学療法の領域, 20, 109-112 (2004)

19. 大久保　正
　　セフメタゾールナトリウム注射製剤溶解時の色調の違いによる製剤の評価．
　　医薬ジャーナル，40, 3304-3310 (2004)

20. 大久保　正
　　ニカルジピン注射製剤の先発医薬品と後発医薬品中のニカルジピン分解物（L-1）含有量の違いに関する研究．
　　医療薬学，31, 121-124 (2005)

21. 大久保　正，大久保　七枝
　　ジェネリック医薬品に対する米国薬剤師の意識調査　第１回
　　米国テネシー州ナッシュビル近郊の調剤薬局薬剤師への調査
　　薬局，56, 2354-2361 (2005)

22. 大久保　正，大久保　七枝
　　ジェネリック医薬品に対する米国薬剤師の意識調査　第２回
　　米国テネシー州バンダービルト大学医療センター薬局薬剤師への調査
　　薬局，56, 2497-2503 (2005)